Mykkanen Martin J

Different Clinical Phenotypes in Monozygotic CADASIL Twins With a ...

From the Department of Medical Biochemistry and Genetics (K.M., M.J., H. Kääriäinen), University of Turku, Finland; the Division of Clinical Geriatrics (K.A., M.V.), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Division of Radiology, Department for Clinical Science (L.B.), Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden; the Department of Molecular Medicine (H. Kääriäinen), National Public Health Institute, Helsinki, Finland; the Department of Medical Genetics (M.P.), University of Helsinki, Finland; the Department of Clinical Genetics (M.P.), Helsinki University Central Hospital, Finland; the Department of Pathology (K.M., H. Kalimo), Helsinki University and University Hospital, Finland; the Department of Pathology (H. Kalimo), Uppsala University, Sweden; the Departments of Pathology and Forensic Medicine (H. Kalimo), University of Turku and Turku University Hospital, Finland; and the Department of Geriatric Medicine (M.V.), Turku City Hospital and University of Turku, Finland. CADASIL is a hereditary arteriopathy causing recurrent strokes and cognitive decline. Because monozygotic twins have identical genetic background, differences in their environment and lifestyle could reveal factors that may influence CADASIL patients’ clinical course, which is highly variable even within the same family.

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